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Aging and autophagosome biogenesis Autophagosome formation rates may fluctuate with age, despite autophagy-related protein levels remaining stable in neurons over time

The copper ionophore disulfiram has been used for decades with sporadic anticancer activity, while its systematic evaluation in AML is still confined to an early-stage trial, highlighting a significant translational challenge for the cuproptosis pathway (214)

Sikiric, P., Gyires, K., Seiwerth, S., et al

The cycle is 30 days on, 30 days off